Constitutive expression and roles of interleukin-8 in canine hemangiosarcoma

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Constitutive expression and roles of interleukin-8 in canine hemangiosarcoma

Results IL-8 mRNA expression was variable among the tissue samples and both IL-8 mRNA and protein were variable among the cell lines. In contrast, IL-8 receptor mRNA and protein showed minimal variance. “IL-8 high” and “IL-8 low” groups were defined from the HSA tumor samples based on gene expression profiles. The “IL-8 high” group was associated with a “reactive microenvironment,” showing enri...

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BACKGROUND Canine hemangiosarcoma (HSA) is a malignant tumor with poor long-term prognosis due to development of metastasis despite aggressive treatment. The phosphatidyl-inositol-3 kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is involved in its endothelial pathologies; however, it remains unknown how this pathway plays a role in canine HSA. Here, we characterized new canine...

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The use of prognostic markers for mammary cancer is important for routine diagnosis and research. Interleukin-8 (IL-8) is a chemotactic cytokine, produced by several cell types in response to inflammation. The expression, regulation and function of IL-8 in dogs are little known. Recent studies have associated angiogenesis and inflammatory processes with tumor malignancy. We investigated a possi...

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To extend our knowledge on the cytokines possibly involved in the pathophysiology of B-cell chronic lymphocytic leukemia (B-CLL), the mRNA expression of a panel of 10 cytokines was investigated on purified B-CLL cells using a reversetranscriptase polymerase chain reaction method. Whereas negative RT-PCR signals were recorded for interleukin-la (IL-la), IL-2, IL-3, IL-4, 11-5, IL-7, tumor necros...

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ژورنال

عنوان ژورنال: BMC Proceedings

سال: 2013

ISSN: 1753-6561

DOI: 10.1186/1753-6561-7-s2-p35